For patients with Ulcerative Colitis, the cycle of remission and flare-up, medication up-titration before augmenting treatment or restarting salvage therapy is one many will know all too well, along with a dawning over time that conventional treatments are no longer enough. That leads many patients to ask tougher questions about what else may be possible. […]

Chronic inflammatory Rheumatoid Arthritis not only restricts the movement of the body, but also the mind, as the simplest tasks of daily living become almost impossible and require phenomenal levels of willpower and determination. The immune system attacks the synovial tissues of the entire body and the pain is nearly constant, further degenerating the overall […]

Tackling The Seen and Unseen Repercussions of Cognitive Decline It’s no secret that Dementia is a huge public health concern. Of all cognitive disorders, Dementia is most devastating as it often means the end of an individual’s ability to live independently. Dementia is characterized by an increasing loss of memory, disorientation to surroundings, altered emotional […]

1.Introduction to the Physical Burden Healthy skeletal tissues are necessary for human physical mobility. When Muscle Degradation occurs, a person’s quality of life is significantly impacted. This condition not only brings major weakness, but also significant loss of skeletal tissue. This can be accompanied by severe psychological issues due to the rapid decline of the […]

Around the world, Alzheimer’s is one of many prominent neurodegenerative diseases that pose a burden on healthcare systems. Currently, millions of people experience a massive deterioration to their cognitive functions because of the relentless and unforgiving effects of Alzheimer’s. Even worse, this disease inflicts its victims with drastic changes to their behaviors, the loss of […]

Introduction: Wound Healing Is More Than Closing a Gap When a wound refuses to heal — whether it is a diabetic foot ulcer that has been present for months, a pressure sore that keeps reopening, or a surgical wound that simply will not close — the frustration for both patient and care team is real. […]

The Other Side of Knee OA | The Role of Subchondral Bone and Inflammation Knee osteoarthritis is characterized by cartilage wear and tear (or cartilage loss). This explanation – although important, as damage to the cartilage is an element of the condition – is too simplistic. In real life, knee osteoarthritis does not only affect […]

Cellular Energy: The Essence of Regenerative Care This stem cell therapy is based on UC-MSCs, but what is the condition of the body after this kind of treatment? Regenerative medicine is not just about delivering cells to the body. It is also about whether the body’s internal environment is ready to respond to supportive cellular […]

The whole-joint disease concept for knee osteoarthritis Knee osteoarthritis is basically described as “wear and tear on your cartilage,” but that version of the story is too simplistic. Cartilage damage is a relevant phenotype, but it reflects only part of the osteoarthritis disease process, as OA involves the whole joint environment. It might vary from […]

Deeper understanding of regenerative support without stem cell injection Regenerative medicine is no longer just about getting stem cell treatment. An even more holistic strategy would also take into account the body’s internal environment before providing cellular support. Inflammation, immune imbalance, poor circulation, metabolic stress, oxidative stress, and cellular energy degradation may all be factors […]

Chapter 1: Introduction–When Even the Act of Breathing is a Burden Every breath they take is a difficult reminder of how different things are for people suffering from COPD, or recovering from recent post-viral lung injury, or chronic lung inflammation. Among the body’s organs, the lungs are among the most biologically complex and structurally fragile […]

Figure 1: UC-MSCs as Supportive Cellular Signaling for Chronic Disease Microenvironment Balance 1.Understanding UC-MSCs Stem Cell Therapy UC-MSCs stem cell therapy – It is a fast-emerging, Umbilical cord-derived mesenchymal stem cell-based as a regenerative medicine. Surveyed for their contributions to cell signaling, immune modulation, homeostasis of inflammation, and health of the tissue microenvironment. One of […]

Understanding Parkinson’s Disease Beyond Dopamine Parkinson’s disease is a neurological problem characterised as a brain illness due to diminished dopamine production. As you can see, dopamine is still not a beneficial neurotransmitter; it helps control movement, co-ordination, muscle tone and day-to-day function. In fact, Parkinsons disease is more than just a loss of dopamine. From […]

Understanding Parkinson’s Disease Beyond Dopamine Introduction: Parkinson’s disease is a type of neurological disease that has been understood to be associated with low levels of dopamine activity in the brain. Dopamine is a key neurotransmitter involved in the control of movement, coordination, motivation, and daily functioning. But Parkinsons is more than just dopamine. It is […]

In fact, Psoriasis is not just a skin disorder for many. It’s this thing they drag around with them in their daily lives: the itching and scaling, redness, flare-ups, discomfort, finding clothing to wear (psoriatic disease), social tension about it all over again, and joint pain that goes along with psoriatic affliction. From afar, someone […]

Syringomyelia is a pathology that rarely comes across the radar of many patients until an MRI, for something else altogether, reveals some incidental finding in their spinal cord. Not a very consumer-friendly term, but an experience all too real: pain, numbness, weakness, stiffness, headaches, changes in sensation, signs and symptoms that creep up on walking, […]

Chronic pain and physical limitations due to injury or disease to the musculoskeletal system is a burden that many people face. Cartilage wears down and degenerates over time, leaving patients less and less able to care for themselves. Persistent damage to joints is debilitating. And unfortunately, existing treatments fail to provide sufficient relief. So, investigative […]

Introductory Comments on the Need for Innovative Therapies for New and Emerging Diseases Systemic Lupus Erythematosus (SLE) is a severe and potentially life-threatening autoimmune disease. SLE has a significant impact on the quality of life for patients. SLE patients are afflicted with chronic fatigue, debilitating joint pain, and irreversible organ damage. In addition to symptoms […]

1. First on SCID: Combined Immunodeficiency – The Effects Severe Combined Immunodeficiency or SCID is a life-threatening condition that is a complete breakdown of the adaptive immune system. Due to this genetic condition, infants are unable to defend themselves against the everyday, non-threatening germs, resulting in a rapid decline in their life expectancy. The impact […]

ALS Is a Complex Neurodegenerative Disease Amyotrophic lateral sclerosis (ALS) is a progressive, neurodegenerative process characterized by the degeneration of motor neurons. They are the nerve cells that control voluntary muscle movement. Motor neurons are the messengers to the muscles, and when they become impaired, it leads to a gradual failure of signaling from the […]