“This comprehensive literature review explores the interaction between developmental pathways in early embryonic neurulation and post-natal central canal remodeling, and acquired hydrodynamic and cellular drivers of pathological central canal dilation in syringomyelia.” Abstract Syringomyelia is a disabling neurological disease in which fluid-filled cavities form in the parenchyma of the spinal cord or in the central canal. Previously these entities were

“This literature review provides an in-depth mechanistic synthesis of how splanchnic arterial vasodilation results in systemic hyperdynamic circulation, vascular hypo-responsiveness and end-organ failure in decompensated liver cirrhosis.” Abstract Decompensated liver cirrhosis is a major clinical watershed with severe systemic complications such as intractable ascites, variceal hemorrhage, hepatic encephalopathy and hepatorenal syndrome. Intrahepatic structural collapse and increased resistance to flow in