Original Issue and Need for Further Advancement
Experiencing physical harm can overwhelm a person and greatly infringe on personal autonomy by making daily activities and routines very difficult to impossible. Muscle Sprains are the most common of the many soft tissue injuries. Fiber bundles can be torn fully or partially, and are among the worst of the injuries. While it is common for athletes to experience these injuries, it can happen to more people than just athletes during everyday activities that employ some level of physical exertion and can become a point of chronic pain. One must then consider the effect far-reaching chronic pain can have on one’s quality of life. The need to innovate particular techniques of safety and restoration becomes a greater priority, as the majority of existing techniques and methods typically fail to facilitate complete restoration. Because of this reason, reconciling the advanced application of biomedicine with a tailored and specific approach using a Stem Cell treatment has become the most viable beacon of hope in addressing chronic muscle weakness. In this case, restoration is more important than symptom relief. The desire for advanced treatment techniques to reduce recovery time in cases of acute trauma is imperative.
Considering Deep Cellular Differentiation
There is a need to articulate these processes at a high precision level. A Stem Cell in its simplest form has immense plasticity. Once these cells come to interact with damaged tissues, they can then undergo the process of myoblast differentiation to aid in the reconstruction of the complex tissue. The process by which these cells reconstruct complex biologically structures is a result of the elaborate intercellular communication networks that are developed by these cells as a result of a control injury to the local area. During cases of severe Myositis or Muscle Sprains, local inflammation can lead to a process of secondary necrosis to the injury. The controlled release of these cells effectively halts this process. Angiogenesis is another aspect of Stem Cell action which regulates the reconstruction of tissues following Muscle Sprains. The formation of new blood vessels facilitates supply of oxygen and removal of waste via the vascular system. Coupled with the modulation of the microenvironment within the tissues, angiogenesis provides complete replacement of tissues, and avoids the formation of rigid fibrotic scar tissues.
Inadequate Systems in Current Practices
Current injury management for Muscle Sprains rely on practices such as rest, ice, compression and elevation. The physician prescribes medication (usually NSAIDs) to manage the symptoms arising from the injuries. Although the conservative management of the injuries have their benefits, they are not without their shortcomings. The use of medication manages pain symptoms as a result of the injuries, and also create a new problem in the form of gastrointestinal complications which arise due to the chronic use of the pain medications. Physical rehabilitation provides better management of the symptoms of the injuries and improves the quality of life of the patient due to regain of mobility. However, extensive structural injury (like a complete rupture of the muscle) does not improve with rehabilitation. The presence of scar tissue deposition in the injured muscle (which is caused by the injury and also a result of the low quality of the repair of the injury) is also debilitating, as the scar tissue has no elasticity, and restricts normal contractile function of the muscle. The compromised structural integrity results in recurrent injuries of the compromised structure. The repeated injuries are extremely frustrating for the affected persons, as the effectiveness of the available management practices plateau. Active persons particularly are vulnerable to the plateau effect. Due to the plateau effect, the need for an alternative that promotes true biological regeneration and healing (like the use of Stem Cell therapy) for optimal recovery becomes imperative.
Reconstruction of the Integrated Biological Structures
The use of advanced biological practices for injury management helps to address the incomplete healing of the injured structures within the body. The predictable recovery of Muscle Sprains is altered with the use of a targeted Stem Cell therapy. When the injury occurs to muscle tissue, the restoration of the internal muscular structures is not the goal. The focus is to make sure that the tissue is healed and reestablish the normal function of the target tissue which is impaired. The primary mechanism for this is biological homing, in which the therapeutic agents localize to areas within the body that are signaling to the cells of the body to migrate to that area.
Once a Stem Cell population is positioned at the center of Muscle Sprains, they integrate and expand into the existing myofiber matrix. This integration provides the mechanical strength required for optimal performance, and because of their immunomodulatory characteristics, they prevent the overactive immune response that typically results in excessive scarring of the tissue. By changing the local macrophage polarization from pro-inflammatory to pro-regenerative, therapeutic agents create a seamless structural continuum. This biological replacement also offers greater tensile strength.
Figure 1: Reconstruction of the Integrated Biological Structures
Reasons for the Success of the Healthcare Market in Southeast Asia
The healthcare market in Southeast Asia is booming. The integration of state-of-the-art hospital infrastructures and specialized clinical expertise makes Thailand the best global destination for innovative regenerative medicine. An intensive and advanced use of Stem Cell technology in the treatment of complex musculoskeletal injuries like Muscle Sprains has particularly gained global attention. The local regulatory climate advocates for innovative clinical research, and the balance of rigorous patient protection and progressive research quickly stimulates innovation. The affordability of advanced treatment has attracted patients from all over the world. Clients for chronic muscle injuries can receive customized therapeutics with the latest technology in cell-processing within regenerative medicine. The local hospitals have integrated the best of traditional hospitality with the latest in regenerative medicine, and provide a holistic recovery experience.