It is a serious global concern for public health. Atherosclerosis is at the root of this issue. Millions of people worldwide suffer from severe Atherosclerosis which leads to life-long pain, limitation, or even death from cardiovascular problems. Such patients live in a state of continuous anxiety, worried about a heart attack or stroke. Conventional medical treatments do not provide a real, long-term solution to this problem. It is essential to pursue new ways in which patient’s lives can be improved. The practice of Regenerative Medicine Thailand has been a breakthrough. It aims to develop ways to repair the full range of structural problems in the body, which puts the focus of therapeutic practice on treating Atherosclerosis at a much earlier, much more repairable, point, rather than managing its symptoms.
A clear understanding of the disease involves the examination of the vascular structure at the micro level. The disease process is started when the protective barrier of the endothelium is disrupted, which in turn is caused by shear stress of the blood or bio-chemically irritative oxidized low-density lipoprotein. Once this barrier is disrupted, an inflammatory response is triggered, causing monocytes to cross the endothelium and enter the intima of the artery, where they differentiate to macrophages and uptake oxidized lipids or become foam cells. The foam cells accumulate and form the first lesion, the fatty streak. Smooth muscle cells proliferate and flow from the tunica media to the intima to cover the lipid core. This fibrous cap, along with the core, is what makes a complex atherosclerotic plaque. A complex fibrous atheroma reduces blood flow through an artery, and with time the fibrous cap can rupture which exposes the atheroma core to blood. This can trigger a cascade of thrombus formation, or a blood clot, which can occlude the artery. The in-depth cellular pathology explains why the primary methods of traditional medicine, such as pharmaceutical and surgical therapies, have been combined with new bio-intervention methods in managing tissue damage at the deep levels of Atherosclerosis, such as those employed in Regenerative Medicine Thailand.
Figure 1: understanding of the Atherosclerosis disease
The primary treatment model in traditional Atherosclerosis medicine is a combination of drugs with various surgical treatments. Statins are at the forefront of the pharmacological treatment by reducing the levels of the cholesterol substance, which, in turn, slows the pace of the atherosclerotic plaques, which, in turn, leads to the stops in the progression of the plaques, as well. In case the treatment through the drugs falls short, the priests of the empirical surgical art of medicine are forced to employ the mechanical methods or Angioplasty and the often-followed ballooning of the arteries with the construction of the bypass to hold the place of the stent to the laid construction of the flowed arteries. In and of themselves, these procedures have a plethora of disadvantages, among which the medical complications are the formation of new signs of the artery having return post-operative occlusion in and of itself and, there is a plethora of additional complications among the medical treatments too. Adverse phenomena, which in this instance are extremely negative, can occur as a result of various medical treatments, including the formation within post-operative periods of occlusion signs in and of themselves as well. The most glaring question regarding all of these methods is that the essence of the problem is left unattended.
To go beyond these types of negative phenomena, it is essential that all required prerequisites be formed to achieve the ultimate goal of all surgical and medical Atherosclerosis interventions, which in this instance is to restore a tissue or organ. Mesenchymal cells then gain the proper characteristics of tissue with ultimate formative properties capable of modulating to an extraordinarily high level in a unique way, as well as a creative inventive way, as well as the secretive and inventive way, as well as the anti-inflammatory secreted factors, which then regulate or modulate the entire phenomenon of vascular growth and stop their progression. Restoration of the endothelium inhibits the formation of lipids deep into the plaque, thereby stabilizing the plaques. Stem cells also promote therapeutic angiogenesis, leading to the formation of collateral blood vessels to ischemic tissues. Cellular therapies act as the cornerstone of Regenerative Medicine Thailand through their ability to repair deep-seated damage to the structural wall of blood vessels. They also have a significant biological advantage over mechanical repairs in the sense that they not only restore the function of blood vessels but also repair the damage caused by the disease.
Figure 2: Comparisons of Traditional Atherosclerosis treatment and Regenerative cellular therapies
Southeast Asia is quickly becoming the new epicenter for advanced medical care, particularly in Thailand. Thailand has a sophisticated, highly specialized, and technically advanced clinical research infrastructure. The expansion of Regenerative Medicine Thailand is due, in part, to support and investment from both the government and the private sector. This growth is also attributable to the presence of highly qualified specialists who have received training in other countries, as well as advanced laboratories. Along with a solid framework for research, Thailand has a commitment to medical reform and a focus on medical tourism. This combination of factors is leading patients with advanced Atherosclerosis to Thailand for care. The synergy of cellular medicine and dedication to the overall well-being of the patient augurs well for Thailand’s position as a leader in the treatment of vascular disease.