Platelet-Rich Plasma (PRP) Treatment for Advanced Joint Degradation and Natural Cellular Regeneration
Introduction to the Origins of Joint Disease
Osteoarthritis remains a leading global cause of physical disability. Millions suffer from a chronic condition that leads to the progressive deterioration of the joints. It begins with mechanical forces at the joints that cause a slow, irreversible, breakdown of the articular cartilage. Severity can escalate from mild, occasional joint pain to a complete loss of function. After losing the ability to complete basic activities of daily living, the priorities of the human body become reset. Real Repair™ and other advanced protocols utilizing Platelet-Rich Plasma (PRP) and cellular technology, begin to use the body’s own biological tools to set a new paradigm for Natural Cellular Regeneration of the tissues that have been depleted, instead of merely masking the symptom with pain.
Pathological Mechanisms
Joint deterioration starts with biological processes being disrupted at the synovial fluid chamber. Chondrocytes accelerate the natural process of programmed cell death, and the localized acute inflammatory response releases destructive enzymes that diffuse into the joint. These enzymes actively destroy the microstructural collagen net, resulting in exposed bone surfaces. This causes patients to suffer from severe localized mechanical instability, agonizing friction of exposed bone surfaces at the joint, and swelling throughout the joint. The inflammatory cycle continuously engulfs the tissue repair process and makes the state of the joint feel worse over time. This hostile environment creates the aggression, and destruction to the protective biological matrix, to the point that in order to stop the deterioration, a biological repair process using Platelet-Rich Plasma (PRP) must be done. Stopping the hostile environment must be done in order to achieve Natural Cellular Regeneration.
Limitations of Managing Symptoms
Traditionally, medical approaches are based on a pharmaceutical model in which symptom management becomes the first priority. A prime example is the over-the-counter oral NSAIDs, which are able to provide short-term relief of pain, but result in a serious gastrointestinal problem after continuous use on a daily basis. Also, the intra-articular injections of corticosteroids provide a short-term relief of the inflammatory response but, after repeated use, studies have shown they may accelerate the thinning of cartilage. Finally, the surgical replacement of the joint is the last option, which comes with a long rehabilitation period and a multitude of other risks. These procedures share a commonality in that they all have a critical structural deficiency, and that is that they fail to address the physical underlying the problem. None of these procedures rely on the principle of Natural Cellular Regeneration, and they are certainly unable to utilize the biological healing processes that do exist, such as Platelet-Rich Plasma (PRP).
Stem Cell Therapy
Stem Cell Therapy is one of the most innovative mechanisms offered by modern restorative medicine. It first began being offered as a means of restorative medicine to allow for the treatment of damaged tissues from the most cellular structures. This therapy is effective as mesenchymal stem cells are introduced to a damaged joint space. Upon introduction of the mesenchymal stem cells to the damaged joint, the stem cells receive the damaged tissues’ inflammatory signals. The stem cells subsequently secrete several histamines (which are growth factors) as a defense against the damaged joint. This is part of the biological repair of the damaged tissues. When Platelet-Rich Plasma (PRP) is used synergistically with stem cell therapy, it acts as biological advancer, assisting in the repair of the joint as well as in the repair of the damaged tissue. The activated platelets provide bioactive proteins to heal the tissues in the joint. This collaboration of stem cells and PRP synergistically works to activate the body’s Natural Cellular Regeneration, thereby allowing the stem cells to transform and repair the damaged cells, ultimately allowing for the repair of the damaged tissues. PRP therapy ensures that the stem cells receive all the nutrients required to allow for complete repair (structural success).
Figure 2: Limitations of Managing Symptoms and Stem Cell Therapy
Developments in Thailand in Regenerative Medicine
Thailand’s pioneering developments in Regenerative Medicine allow it to become a global leader in medical breakthroughs, while integrating advanced regenerative protocols into Thailand’s medical facilities will allow Southeast Asia to become a global leader in medical technology. Thailand’s pioneering developments in biotechnology, including Platelet-Rich Plasma (PRP), enables Thailand to further promote its position in the world as the leader in Natural Cellular Regeneration. Thailand’s world-class facilities in innovative biotechnologies, coupled with world-class personnel in medical biotechnology and biomedicine, enables Thailand to further develop its world-class safety regulations. Thailand’s medical facilities provide a world-class environment for patients to heal, and Thailand’s top-of-the-line specialized facilities provide a world-class environment for patients to heal. Thailand’s medical facilities provide patients with healing programs and a world-class environment for patients to heal, and Thailand’s medical facilities provide patients with healing programs and a world-class environment for patients to heal. With the world-class medical facilities, healing programs, and a world-class environment for patients to heal, Thailand’s medical facilities will provide a world-class environment for patients to heal.