Chronic high blood sugar has a debilitating effect on the endothelial linings within the blood vessels of the entire human body. This persistent degradation manifests in diabetic vascular aging. Patients suffer multi-dimensional microvascular and macrovascular sequelae which impairs mobility and endangers life. Metabolic changes damage blood vascular surfaces deeper in the body within the intimal layers of blood vessels. As a result, the global population is afflicted by severe and complex cardiovascular diseases. The medical profession is in dire need of innovative strategies to mitigate the damage. Anti-Aging Stem Cell Nutrition is proposed to be an integrative approach to repairing damaged endothelial tissues. Further, advanced therapeutic approaches bring great optimism to the people whose lives have been adversely affected to such an extent that they wish to regain their vitality.
Diabetic vascular aging is a result of complicated biochemical processes that stem from chronic oxidative stress, coupled with advanced glycation end-products. These chronic oxidative stress end products damage the vascular endothelium and cross-link the vascular walls that make up the extracellular matrix that make the walls of the vessels elastic. Reactive oxygen species cause vascular smooth muscle cells, which damage the mitochondria, hyper proliferate. This leads to the vessel walls thickening and arteriosclerosis. This vascular thickening and endothelial dysfunction lead to a lack of nitric oxide in the blood vessels, which causes vasodilation and systemic hypertension. Patients then suffer severe and significant tissue hypoxia from such cardiovascular changes, and experience a plethora of incapacitating symptoms such as claudication, ulcer formation, and even myocardial infarctions. This diabetic vascular aging is a result of cellular aging which inhibits the body’s ability to regenerate and necessitates Anti-Aging Stem Cell Nutrition to support the body’s repair mechanisms. The failure of repair mechanisms within tissues leads to the secretion of pro-inflammatory cytokines by aging endothelial cells, which further induces endothelial dysfunction which restricts endothelial cells from vasodilation. Further the aging of endothelial cells within the blood vessels leads to greater microvascular damage, and severe hypoxia within the vessels. Macrophages also enter the tissue and further proliferate within the endothelial layers, causing a thickening of the vessel walls and progressive atherosclerosis. This vicious cycle leads to a greater disruption of the tissues within the organ systems which leads them to be a prime target for complete organ failure.
Most of the current treatment options involve symptom management through the use of pharmaceutical agents. Physicians seek to control hypertensive and cardiovascular risks through prescriptions of beta blocker antihypertensive agents and statin and antiplatelet drugs. Control of blood sugar remains a primary focus, and this control is achieved through the use of insulin and oral hypoglycemic agents. These modalities of treatment slow the nature of diabetic vascular aging, but they do not reverse damage to the cells. Medications also do not heal necrotic tissues or the loss of capillary networks. Surgical options attempt to treat the problem through angioplasty and bypass grafts, both of which come with significant perioperative risks to the frail population. The constraints of the current modalities of treatment require a strategic and drastic change to a focus of treatment that centers on regenerative medicine using Anti-Aging Stem Cell Nutrition.
Using Anti-Aging Stem Cell Nutrition, regenerative strategies offer an entirely new paradigm of addressing the vascular degenerative process. Given their unique properties, mesenchymal stem cells have both angiogenic and immunomodulatory properties. When introduced to the body, these progenitor cells demonstrate the ability to migrate to the site of an injury that encompasses the endothelial layer of the vascular system. These progenitor cells have the ability to produce paracrine factors that are similar to the vascular endothelial growth factors, thus helping facilitate vascularization and the establishment of new blood vessels. These progenitor cells also demonstrate the ability to produce extracellular vesicles that contain microRNA that have the ability to modify the endothelial cells and foster the development of new capillary networks. This establishes the ability to breathe new life and offer adequate oxygen delivery to necrotic tissues. Targeted nutrient protocols foster and enhance the environment toward the sustained survival and incorporation of the administered progenitor cells. These nutrients are also the precursors to sustained telomere length, thus providing a longer reproductive lifespan of the progenitor cells. These nutrients support cellular health and minimize the effects of diabetic vascular aging, and these nutrients minimize and eventually dissolve the aging cross links. This eventually restores deformed blood vessels, offering optimal vascular health and elasticity, especially in the blood vessels that were starting to become gravely ischemic and destined for amputation.
In Thailand, the development in this branch of cardiovascular medicine is significant and taking center stage. Thailand has become a leading global provider of Anti-Aging Stem Cell Nutrition because of its state-of-the-art medical infrastructure, high level of investment in biotechnology, and clinical trials in regenerative therapy. The country’s sophisticated medical environment also offers medical tourists low-cost and vertical solutions in regenerative therapy. International collaborations between Thai nationals and visitors in stem cell therapy and biomedicine also improve regenerative therapy in the Coast of the Thai Gulf, as access to the Gulf’s rare and various ecological and botanical biodiversity make it possible to develop a supportive matrix for stem cell therapy, as is currently being researched. Additionally, borders along the Indigenous Thai shores give a rare diverse ecosystem and biomes which are to be Phyto planted as supportive matrices for stem cell therapy. The incentive to integrate cell therapy restoratives and cure diabetic vascular aging is enormous.