Cutaneous Hyperpigmentation and its Impact Cutaneous hyperpigmentation is one of the more complex areas of medicine and can detrimentally affect the quality of life for the patients. Those suffering from Dark Patches can develop psychosocial disabilities, including anxiety and depression. Such conditions can affect one’s ability to participate fully in social activities. This condition is more than cosmetic; it can be emotionally burdensome for affected individuals. It is common for individuals to withdraw from social activities, including affected individuals with Dark Patches on the face, who become less social because of the inability of standard makeup to conceal them. Such Dark Patches are often resistive to standard forms of treatment such as topical treatments, and these individuals often seek other forms of treatments (regenerative and restorative techniques). PhytoCellTec Technology employs such advanced and complex cellular techniques and can be able to target the deeper layers of the skin, including the cellular micro-environment, and beyond the upper epidermal surfaces that can cause exfoliation.
Mechanism of Occurrence
This would represent highly localized areas of lost hyper-pigmentation. These areas can be caused by a defect in the synthesis of pigment and there can be localized hyper-pigmentation (excessive synthesis of these pigments or irritants). Such localized hyper-pigmentation can be caused by excessive ultraviolet radiation or some type of excess hormonal stimulation of the epidermal basal layer. Such stimulation of the epidermal basal layer can cause increased generation of reactive oxygen species, and in turn can cause excessive oxidative stress, which can catalyze the excessive and rapid activation of tyrosinase enzymes. These in turn, catalyze the excessive and rapid conversion of tyrosinase to more complex and denser forms of melanin, which in turn, can cause an over-active localized immune response to excessive melanin, transferring this melanin to the surrounding keratinocytes of the epidermis. These pigment-laden keratinocytes can migrate out of the epidermis, thus causing highly visible Dark Patches on the outer layers of the skin, an underlying issue that PhytoCellTec Technology aims to mitigate.
Traditional Invention and Limitations
Clinical manifestations may present as Dark Patches that are often asymmetrical and are bordered by demarcated hyper-pigmented spots that may vary in pigmentation in intensity. Visual severity is often inconsistent and depends on the patient’s environment. Chronic lesions eventually migrate and settle at the dermal epidermal junction. Treating patches of darker skin resulting from post-inflammatory hyperpigmentation is even more difficult due to the high structural density melanin has, which is the result of a complex interplay of various molecular mechanisms. The post-inflammatory hyperpigmentation is unlikely to respond to clinical treatments that predominantly cause trauma to the skin and melanin of the uppermost layers. During most of its practice, the field of dermatology has relied fully on tragic chemical, botanical and mechanical methods accompanied by great physical discomfort. It was common practice to prescribe strong topical hyperpigmentation agents (especially skin-bleaching creams) to block the increased expression of Melanogenesis enzymes (tyrosinase). Chemical peel treatments, involving both superficial and deep dermal levels, aimed to promote hyperemia and accelerate dermal and epidermal turnover. Laser Interventions and other photo selective techniques aimed to destroy the melanin along the skin. Unfortunately, burning methods cause great discomfort, and pain during and after the procedure. Long exposure to the post-inflammatory hyperpigmentation deeply disrupted epidermis and dermis barrier function. After the pain has ceased, the post-inflammatory hyperpigmentation often induces deep post-inflammatory hyper-pigmentation. As a result, the condition appears especially frustrating. Traditional dermatology has relied too much on chemical and traumatic techniques and has neglected the molecular and cellular mechanisms underlying post-inflammatory hyper-pigmentation, a gap effectively addressed by PhytoCellTec Technology.
The PhytoCellTec Technology for Healing Processes of Skin
Clinical and botanical methods of therapy with the help of the phytogenic stem cells, are perfect in the healing processes of skin. PhytoCellTec Technology is the mitosis technology of the plant cells to communicate to the human epidermis and interlayer cells where collaboration and cooperation of the signaling system exist. The plant-derived metabolites protect and also penetrate the stratum corneum breach and interfere with the function of the targeted deeper level derma cells. These bioactive compounds decrease the microphthalmia associated transcription factor. This transcription factor represses the expression of tyrosinase, reducing its overall production. PhytoCellTec Technology also enhances local dermal fibroblasts stimulation. Because dermal fibroblasts contribute to support the dermal network with an extracellular matrix, this reinforcement will eventually cause those cells to remove the upper keratinocytes of the dermis. This cellular replacement will eventually remove the cause of the pigmentation, leading to the fade of Dark Patches over time.
Future Trends in Thailand
The high UV exposure in Thailand, often in the range of 12-16, leads to photodamage. Together with Thailand’s high prevalence of pigmentation disorders, there will be an increase in the use of bioengineered botanicals to alleviate the signs of fast aging associated with Dark Patches. PhytoCellTec Technology fully supports Thailand’s push toward higher tiered, premium, quality aesthetics. This disruption in the use of aggressive, highly destructive lasers in summer months supports Thailand’s therapeutic alternative of cellular botanicals to ease them through the summer month safely.