It is now widely recognized that the ability to function fully in the male sexual role is critically important to the male’s sense of general wellbeing and to his emotional stability. When severe Erectile Dysfunction occurs, the psychological trauma and emotional suffering can often exceed the physical suffering. The lack of a fully functional sexual role is damaging to intimate relationships and can be a cause of significant distress for the male, due to the loss of confidence that can be detrimental to the male sex in general. Restoration of normal sexual function is the ultimate goal of this therapy, and both the aim and the challenge are to develop a treatment that will reverse the lack of function and restore the normal physiological and psychological tissue. The mental health ramifications of Erectile Dysfunction are severe and need immediate treatment. Thailand is extremely focused on the development of Stem Cell Therapy in Thailand fully restore normal and healthy physiological function.
1. Erectile Dysfunction Mechanism
In considering the treatment of dysvascular Erectile Dysfunction, it is important to have an understanding of the physiological mechanisms underlying a normal erection. The process of tumescence begins with sexual arousal and rapid stimulation of the central nervous system. The release of nitric oxide as a result of endothelial cell stimulation in the corpus cavernosum activates guanylate cyclase, resulting in an increase in the intracellular concentration of guanosine cyclic monophosphate. This is rapidly followed by relaxation of the smooth muscle of the cavernous sinus and the rapid inflow of blood. The expansion of the sinuses and the bordering tunica sub compressive venules results in increased penile rigidity. In the majority of cases of Erectile Dysfunction, the coordination of the vascular and neurologic orchestra completely ceases to function. The main problem in this orchestra is the failure of the endothelial system and the reduction of nitric oxide availability in the systemic circulation. An overabundance of free radicals results in the destruction of the delicate endothelial vessels. Healthy smooth muscle is progressively replaced with fibrotic scar tissue, leading to a critical loss of the biological function of veno-occlusive tissue. Modern Stem Cell Therapy in Thailand effectively addresses these specific microenvironmental cellular malfunctions.
Figure 1: Erectile Dysfunction Mechanism
2.Traditional Erectile Dysfunction Treatments
Current medical Erectile Dysfunction practices rely on prescribing phosphodiesterase type 5 (PDE5) inhibitors. These oral medications extend smooth muscle relaxation by delaying the natural breakdown of cyclic guanosine monophosphate. While they are somewhat effective, they delay total relaxation and provide only a temporary solution to the symptoms. Once patients take these medications, they must time the dosages to expected sexual activities to regain some measure of normalcy in their intimate relationships, and on occasion, this dosage must be adhered to rigidly, further detracting from sexual spontaneity. In addition, these PDE5 inhibitors have adverse side effects, such as chronic headaches. If the oral medications do not work, patients must endure Intracavernosal injections (ICI) of powerful vasodilation medications directly into the penile erectile tissue. These injections cause intense pain to the target tissue where the drug is administered. External vacuum erection devices are an additional invasive option, but are still very impractical. Penile prostheses are the ultimate invasive option. These treatments are inadequate of even beginning to treat the real pathology of the Erectile Dysfunction.
3. Stem Cell Therapy in Thailand
Regenerative biological medicine provides a cellular alternative to the perpetual and indefinite management of Erectile Dysfunction in older males. Sophisticated Stem Cell Therapy in Thailand utilizes isolated mesenchymal stem cells derived from potent umbilical cord tissue. These cells possess substantial immunomodulatory physiological properties. Once they are directed to cavernous tissues, they have the capability of releasing large quantities of growth factors that are bound to special extracellular vesicles. This scientifically proven paracrine signaling initiates local tissue repair with the secretion of a cocktail of molecular factors. Vascular endothelial growth factor is an excellent early-stage angiogenic factor that induces the rapid development of blood vessel networks and brings new blood supply to tissues. Its secretome promotes the survival of endothelial cells by inhibiting programmed apoptosis. Additionally, the anti-fibrotic proteins in the secretome help in the resolution of the dense collagenous scar tissue in the corpus cavernosum. The degradation of the cellular matrix brings back the natural elasticity of the tissue. The secretome promotes the regeneration of the nerves and the restoration of erectile function. This is the reason for the superiority of this regenerative protocol.
Figure 2: Comparing Erectile Dysfunction treatment
4. Future Trends
The future of Stem Cell Therapy in Thailand is geared towards the personalization of regenerative cell therapy. The ongoing clinical trials continue to advance the techniques to increase the viability of cells during transplantation. There are hopes in the medical field that in this decade of technology we will have the first unified standards in biomedicine and safe application of stem cell therapy. Thailand has emerged as one leading country in this area. The country has invested in the development of their research and regenerative medicine. Researchers are working to stabilize and add pharmaceutical compounds to optimize the therapy. The new laws prioritize the safety of the patients to the greatest extent and allow the rapid advancement of medical technologies. There are Erectile Dysfunction patients that come from all over the world for procedures that will restore erectile function.