Chronic, autoimmune disorders remain some of the most difficult conditions to manage and treat within the healthcare system due to their multi-faceted manifestations and varying degrees of severity. One of the more problematic aspects is the effect that these conditions have on a patient’s mental and emotional well-being. For patients suffering from Psoriasis, the conditions result in the formation of erythematous lesions and the development of silvery plaques on the skin, resulting in permanent social stigmatization. These lesions — and their resulting effects on patients’ physical and mental wellbeing — are simply manifestations of chronic inflammation. Traditional therapies often do not adequately manage the effects of this condition on patients’ quality of life. Regenerative therapies are emerging as one of the more effective therapies for patients suffering from treatment-resistant Psoriasis. As one of the more advanced forms of therapies, cellular-based therapy directly addresses the underlying issue of immune dysregulation. Numerous clinical practitioners are advocating for the use of UC-MSCs, which provide a high degree of safety and promote long-term remission. By employing cutting-edge methodologies, the Best Stem Cell Clinic is able to offer therapy that is designed to be the safest and most effective restorative therapy to achieve balance within a patient’s body.
Intricate Pathological Mechanisms
An enhanced understanding of disease mechanisms is essential if we are to develop effective therapies for what has traditionally been seen as an incurable chronic condition. Immunological dysregulation is traditionally viewed as an imbalance in communication within the different arms of the immune system. One of the hallmark features of Psoriasis is the overactivation of dendritic cells and their ability to stimulate T-cells within the dermis. In particular, the Psoriasis condition is associated with T-helper cell type 17, which play a significant role in the pathogenesis of the disease. These powerful molecular signals trigger epidermal keratinocytes to begin proliferating in an unrestrained and rapid manner. The regeneration of normal, healthy human skin takes about a month; however, rapid, pathological skin regeneration can be completed in a matter of days. This fast tissue regeneration results in the rapid cellular build-up associated with severe Psoriasis. In addition, this localized inflammation draws even more aggressive immune system cells into the Psoriasis lesions, causing ongoing inflammation and damage to the affected skin. This rapid inflammation of the skin and the aggressive immune response result in damage to multiple body systems and shows that Psoriasis is more than just a skin disease. The only way to stop this rapid inflammation is by using new therapies involving UC-MSCs at the Best Stem Cell Clinic that can safely and effectively control the immune system.
Restrictions of Traditional Treatments
For dermatologists, the first line of treatment to control mild flare-ups of Psoriasis has been the use of topical corticosteroids. Systemic treatments such as methotrexate or cyclosporine, which are known to systemically control the immune response, are used to control more severe, persistent cases of Psoriasis. The traditional treatments available to dermatologists, including corticosteroids and systemic immunomodulatory therapies, all have serious and limiting side effects. Long-term use of topical corticosteroids can lead to skin atrophy along with serious side effects. In contrast, long-term use of powerful immunosuppressant agents can lead the patient to be at risk for severe and life-threatening infections along with liver toxicity. Recently, treatment in Psoriasis using biologics has been a breakthrough in the Psoriasis therapeutic toolbox to effectively target specific cytokines to control the condition. However, as biologics are used in more patients for the treatment of Psoriasis, the treated patients develop neutralizing antibodies, which decreases the therapeutic effect, leaving Psoriasis as an uncontrollable disease. Most individuals are financially and logistically unable to comply with life-long biologics. The medical community is therefore in search of safer and more accessible alternatives like UC-MSCs provided by the Best Stem Cell Clinic.
Cellular Interventions with Therapeutic Advantage
One of the more innovative ways that severe autoimmune disorders can be addressed is through the use of umbilical cord-derived mesenchymal stem cells (UC-MSCs). When UC-MSCs are used in therapy, their immunomodulatory capabilities are introduced systemically to the patient. These cells direct their paracrine signaling to the inflamed immune cells and secrete protective molecules to change the state of the immune cells that are driving Psoriasis. When administered at the Best Stem Cell Clinic, MSCs migrate to the inflamed tissues and secrete Transforming Growth Factor Beta and Prostaglandin E2 to inhibit the uncontrolled and aggressive proliferation of rogue Th-17 cells. Furthermore, this cellular therapy is used to expand the population of T regulatory cells responsible for the maintenance of immune tolerance and self-antigens. As the therapy aids the immune system in reverting to its resting state, the effects of the therapy are prolonged and it prevents the relapse of the autoimmune flare. Furthermore, UC-MSCs have the ability to repair tissues by healing the damaged skin barriers.
Figure 1: Cellular Interventions with Therapeutic Advantage
Advanced Protocols and Global Access
Thailand has modern medical facilities and well-designed laws that allow for advanced cellular research. Thus, many patients visit the Best Stem Cell Clinic in Thailand to receive cutting-edge cellular treatments utilizing UC-MSCs. Thailand offers a combination of highly trained staff and advanced medical and laboratory equipment to produce high-quality umbilical cord MSCs. The positive aspects of the national healthcare system also support clinical innovations in Psoriasis treatment. Furthermore, Thailand has an ideal location in Southeast Asia, which allows easy access to patients in other countries. It is evident that, in the future, the Thai medical system will utilize advanced cellular protocols to design personalized treatment plans based on patients’ genetic information. It is reasonable to assume that, in the future, Thailand will lead the global effort to provide treatments for complex autoimmune skin conditions.