Traumatic Brain Injury (TBI) can have life-altering consequences and is an event that millions of people suffer from each year. TBI occurs when there is trauma to the skull (and thus the brain). Those who survive a Traumatic Brain Injury are often left with debilitating cognitive and motor impairments. Because of the level of care required by individuals who have sustained a TBI, their families are burdened to care for them and the community is forced to financially support them. Traditional approaches to treating TBI have proven to be inadequate to fully restore brain function. This gap in treatment is the impetus for the use of more advanced approaches to Regenerative Medicine. The use of Umbilical Cord Mesenchymal Stem Cells (UC-MSCs) will increase the efficacy of treatment. By incorporating more advanced methods, such as Stem Cell Therapy Thailand options, medical professionals will have the opportunity to treat patients beyond the management of symptoms to the restoration of lost brain function. The advanced use of Stem Cell Therapy Thailand has the potential to give patients their autonomy back.
UC-MSCs Mechanism in Traumatic Brain Injury
Like many cells within the body, UC-MSCs have the potential to communicate with, and restore, other cells damaged by a Traumatic Brain Injury. The ability of UC-MSCs to restore a cell’s function is largely due to their ability to secrete paracrine signaling molecules. After being administered intravenously during Stem Cell Therapy Thailand protocols, UC-MSCs migrate to the areas of the brain that sustained injury. They can secrete a wide variety of neurotrophic factors. Some of these factors include Brain-derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF). These two factors also play a role in the survivability of neurons. UC-MSCs can also help modify the body’s immune response. UC-MSCs can promote the transformation of harmful, pro-inflammatory M1 Microglia (cells of the immune response that have entered the brain) to the anti-inflammatory M2 Microglia. This shift helps to reduce the spread of inflammation to other areas of the brain, which may help to decrease the size of the original lesion. Delivered via Stem Cell Therapy Thailand, each UC-MSCs capsule metabolically targeting the neural tissue contains microRNAs designed to cross the blood-brain barrier following a Traumatic Brain Injury. In the injured neural tissue, genetic signals obstruct the execution of cell death in the tissue of the damaged brain.
Traditional Traumatic Brain Injury Treatments
The majority of traditional treatments for a Traumatic Brain Injury concentrate on the acute stabilization of the patient, lacking the regenerative power of UC-MSCs. Surgeons decompress the skull by removing fragments to relieve the dangerous pressure inside the skull. They usually rely on pharmacological methods to decrease swelling of the brain. After the survival of the initial trauma, patients are subjected to long and tedious physical rehabilitation. Therapists assist the brain in its survival of the injury to reestablish the neural pathways by means of physical exercises of a repetitive nature. The limitations of these methods are clear and permanent, unlike modern Stem Cell Therapy Thailand alternatives. Surgical methods of intervention are only used to prevent death and cannot restore the integrity of the affected tissue. Rehabilitation is used for years and even decades, but the resulting merely in the stabilization of surviving neural pathways. The traditional medicine approaches to Traumatic Brain Injury cannot restore the integrity of brain tissue and the methods are not truly regenerative. No new functioning neural cells can be created. The old methods of medicine cannot fulfill the demands of a truly regenerative approach utilizing UC-MSCs.
Substituting With New Treatments
New, truly regenerative methods replace, address, and fulfill what old, non-regenerative methods have failed to do for a Traumatic Brain Injury. Implementations of Stem Cell Therapy Thailand in the clinical practice of regenerative medicine are a perfect example of a successful substitute. The new method works because UC-MSCs stop further injury to the brain and begin the process of creating functional cells in the brain by generation of new neural cells. Strong angiogenesis is the other key mechanism involved. Transplanted UC-MSCs promote the formation of new blood vessel networks in the areas of the brain which have suffered ischemic penumbra.
Facilitated by Stem Cell Therapy Thailand, this new blood flow brings regions in the brain that have been starved of oxygen back to life after a Traumatic Brain Injury. Activated by UC-MSCs, the brain develops new microenvironments by regaining structural plasticity. Rather than creating permanent scars, the treatment directs the body to eliminate glial scars. With the glial scars removed, new axons can be extended and reconnect previously lost circuits. This reshaping of tissue is another example of the biological tools that need to be incorporated more and more to supplant existing palliative care models.
Figure 1: Traditional Traumatic Brain Injury compared with Regenerative methods
Regional Trends in Thailand
The relocation of regenerative medicine to Southeast Asia shows the benefits regions can have as the country develops a uniquely robust infrastructure for Stem Cell Therapy Thailand. Thailand combines top level care with positive regulatory attitudes towards UC-MSCs and cellular research. This positive attitude surrounding policy permits scientists to complete a majority of research via rapid clinical pathways and time-efficient courses, all the while maintaining an appropriately rigorous standard of care for a Traumatic Brain Injury. This clinical research and therapy model draws in world-renowned researchers. It is also a cost-effective model for international patients. The future is a complete shift towards cellular prescriptions designed for each individual patient. This new convergence ensures Thailand becomes the leading country for treatment of a Traumatic Brain Injury utilizing UC-MSCs.