As regenerative medicine continues to evolve, understanding the patient’s immune system is becoming essential for the success of stem cell therapy. One important marker that plays a critical role in this process is HLA-DR. At Vega Stem Cell Clinic in Bangkok, we utilize advanced diagnostic tools and immune profiling including HLA-DR analysis to enhance treatment safety, precision, and outcomes.
What is HLA-DR?
HLA-DR is a type of Human Leukocyte Antigen (HLA), specifically a class II surface receptor found on immune cells such as B lymphocytes, dendritic cells, and macrophages. Its primary function is to help the immune system recognize and respond to foreign substances, including viruses, bacteria, and transplanted cells.
In the context of stem cell therapy, HLA-DR expression can indicate:
- Immune system activation or inflammation
- Risk of immune rejection
- Suitability for certain types of stem cell transplants
- Progression of autoimmune or chronic inflammatory diseases
Why HLA-DR Matters in Stem Cell Therapy
Stem cell therapy involves introducing new cells into the body to regenerate or repair damaged tissues. While umbilical cord-derived mesenchymal stem cells (UC-MSC stem cells) used at Vega Clinic are generally immune-privileged (low risk of rejection), understanding the patient’s HLA profile especially HLA-DR can help in the following ways:
Reducing Risk of Rejection
Measuring HLA-DR compatibility or activation can help predict immune responses, ensuring stem cells are not attacked by the host’s immune system.
Personalizing Treatment
Patients with elevated HLA-DR levels may have ongoing inflammation or autoimmunity. Tailoring stem cell dosage and delivery methods (e.g., IV vs. intrathecal) based on HLA status improves outcomes and safety.
Monitoring Autoimmune Activity
HLA-DR is often elevated in autoimmune diseases like lupus, rheumatoid arthritis, and multiple sclerosis. Stem cell therapy can help modulate these overactive immune responses.
Enhancing Stem Cell Efficacy
By understanding the immune environment through HLA-DR profiling, clinicians can time and target therapy more effectively, especially in chronic inflammatory or neurological diseases.
Conditions Where HLA-DR Testing is Useful Before Stem Cell Therapy
- Rheumatoid arthritis
- Multiple sclerosis
- Systemic lupus erythematosus
- Type 1 diabetes
- Hashimoto’s thyroiditis
- Chronic fatigue or post-viral inflammation
- Long COVID symptoms
- Autism Spectrum Disorder (immune-related cases)
HLA-DR Testing at Vega Stem Cell Clinic Bangkok
At Vega Stem Cell Clinic, we offer optional HLA-DR testing as part of our advanced patient screening protocol for those with autoimmune, inflammatory, or complex conditions. Our commitment to personalized, science-backed regenerative care means every patient receives a tailored approach that maximizes benefits while minimizing risks.