Articles

Mesenchymal Stem Cell Therapy for Autism Spectrum Disorder: A Regenerative Breakthrough

Autism Spectrum Disorder (ASD) is a neurodevelopmental condition marked by persistent difficulties in social interaction, communication, and the presence of restricted or repetitive behaviors. The severity and presentation of symptoms vary widely among individuals, contributing to the term “spectrum.” While…

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Thailand’s Stem Cell Solutions for Osteoarthritis Using Umbilical Cord–Derived Cells

Osteoarthritis develops slowly, beginning with the gradual breakdown of cartilage—the smooth, cushioning tissue that allows joints to move fluidly. As this protective layer wears away, bones begin to rub directly against each other, causing persistent discomfort, stiffness, swelling, and reduced…

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Regenerative Knee Treatment With Umbilical Cord–Derived Mesenchymal Stem Cells in Thailand

Knee deterioration and persistent discomfort are among the most common orthopedic problems affecting people of all ages. These conditions can lead to reduced mobility, disrupt everyday activities, and negatively impact overall well-being. Traditional treatments for knee issues often focus on…

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Umbilical Cord–Derived Mesenchymal Stem Cell Regenerative Treatment for Diabetic Foot Ulcers in Thailand

Diabetic foot ulcers (DFUs) remain one of the most serious and long-standing complications associated with uncontrolled or long-term diabetes. Even with modern advances in blood sugar control and wound care, these ulcers frequently resist healing, recur after initial recovery, and…

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Mesenchymal Stem Cell Therapy in Idiopathic Pulmonary Fibrosis: A New Approach in Lung Disease Management

Idiopathic pulmonary fibrosis (IPF) is a severe and progressive lung disorder characterized by scarring and thickening of the lung tissue, which hinders effective oxygen exchange. Primarily affecting individuals over the age of 50, IPF’s exact cause remains unknown, hence the…

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MSC Secretome as a Regenerative Strategy for Parkinson’s Disease

Parkinson’s disease (PD) is a progressive neurodegenerative disorder that leads to tremor, rigidity, slowness of movement, and postural instability. The disease primarily results from the loss of dopaminergic neurons in the substantia nigra and widespread neuroinflammation. While conventional medications such as levodopa can relieve symptoms, they…

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Mesenchymal Stem Cell (MSC) Therapy for Parkinson’s Disease Premotor Symptoms

Introduction Parkinson’s Disease (PD) is a progressive neurodegenerative disorder characterized by motor symptoms (tremor, rigidity, bradykinesia) and non-motor or premotor symptoms (NMS) such as depression, anxiety, sleep disturbances, and cognitive decline. These non-motor manifestations often appear years before classical motor signs, indicating a prolonged…

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Literature Review: Neuroinflammation in Autism Spectrum Disorder and the Therapeutic Role of Mesenchymal Stem Cells (MSCs)

Background Autism Spectrum Disorder (ASD) is a multifactorial neurodevelopmental condition associated with social and behavioral difficulties, communication deficits, and sensory abnormalities. Emerging evidence indicates that neuroinflammationplays a central role in ASD pathology. Chronic activation of microglia and astrocytes, elevated cytokine levels,…

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A Regenerative Advancement in the Treatment of Diabetic Wounds: UC-MSC Stem Cell Therapy for Diabetic Ulcers

Diabetic ulcers, especially those occurring on the feet, are among the most frequent and serious complications of diabetes. These chronic wounds affect nearly one in four diabetic patients during their lifetime and are a primary cause of lower-limb amputations. Despite…

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“Clinical Utility of Mesenchymal Stem/Stromal Cells in Regenerative Medicine and Cellular Therapy” by Maldonado et al., Journal of Biological Engineering (2023) Clinical Utility of MSC Stem Cell in Regenerative Medicine

1. Overview of MSC Stem Cell Mesenchymal stem/stromal cells (MSCs) are multipotent somatic stem cells capable of self-renewal, multilineage differentiation, and strong immunomodulation. They can be derived from multiple sources such as bone marrow, adipose tissue, umbilical cord, placenta, amniotic…

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A Next-Generation Approach to Chronic Lung Disease with UC-MSC Stem Cell Therapy in Thailand

Chronic lung diseases—such as COPD, pulmonary fibrosis (including post-viral/Post-COVID fibrosis), severe asthma, and bronchiectasis—are major causes of disability worldwide. Progressive inflammation and, in many cases, scarring (fibrosis) reduce gas exchange, leading to breathlessness, cough, exercise intolerance, and frequent exacerbations. While inhaled therapies, antifibrotics, and oxygen…

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