An autoimmune condition that affects the thyroid gland, Hashimoto’s thyroiditis, is being studied as a possible treatment with stem cell therapy. This investigation is necessary since existing treatments, including as immunomodulatory therapy, thyroid hormone therapy, and surgery, have dangers and limits that make them ineffective in managing the condition. Get additional information about the dangers of the available treatments.
Using Mesenchymal Stem Cells (MSCs) to Treat Hashimoto’s
Th17 and Treg cells are essential for the autoimmune reaction of Hashimoto’s thyroiditis, and MSCs aid in their equilibrium. MSCs have been suggested as a potential immunotherapy by research employing a rat model, which revealed that rats treated with MSCs had less thyroid autoantibodies, fewer thyroid lesions, less lymphoid infiltration, fewer Th17 cells, and more Treg cells. Go here to learn more about this study.
Advantages
A promising treatment option for Hashimoto’s thyroiditis, an autoimmune disease that affects the thyroid gland, is stem cell therapy. The potential of the treatment resides in its capacity to alter immune responses and potentially promote thyroid tissue regeneration. It’s important to take into account the therapy’s inherent hazards, such as the potential for autoimmune disease transmission.
Important Advantages of Immunomodulatory Effects of Stem Cell Therapy:
- In Hashimoto’s autoimmune response, mesenchymal stem cells (MSCs) play a critical role in balancing Th17 and Treg cells. MSC therapy increased Treg cells and decreased thyroid autoantibodies, thyroid lesions, lymphoid infiltration, and Th17 cells in a rat model.
- Inducing Immune Tolerance: Human limbal fibroblast-like stem cells can induce tolerance in autoreactive T lymphocytes in Hashimoto’s patients, suggesting a reduction in autoimmune responses.
- Differentiation Potential: Stem cells have the ability to differentiate into thyroid follicular cells, which could lead to the development of treatments for autoimmune thyroid disorders.
Knowledge about Hashimoto’s Disease’s Thyroid Gland Functions and Thyroid Stimulating Hormone using mesenchymal stem cells (MSCs)
An autoimmune condition that affects the thyroid gland is Hashimoto’s thyroiditis, sometimes referred to as chronic lymphocytic thyroiditis. This disorder causes inflammation and damage to the thyroid tissues when the immune system unintentionally targets the thyroid gland. In recent years, there has been interest in the potential of mesenchymal stem cells (MSCs) to treat and comprehend Hashimoto’s disease.
Thyroid hormones are produced by the thyroid gland and are necessary for controlling metabolism and other critical bodily processes. These hormones’ synthesis and release are regulated by thyroid-stimulating hormone (TSH). Thyroid tissues are destroyed and thyroid lesions are formed in Hashimoto’s disease when autoantibodies, such as antibodies to thyroid peroxidase (TPO), are present. Hypothyroidism results from the gland’s decreased ability to produce hormones.
Using Mesenchymal Stem Cells to Treat Autoimmune Conditions, Such as Hashimoto’s
MSCs have demonstrated potential in reducing the impact of autoimmune illnesses, such as Hashimoto’s, whether they are produced from human adipose tissue or umbilical cord tissue sources. These multipotent stem cells have the ability to enhance cardiac progenitor cell survival, stimulate tissue repair, and alter the immune system. MSCs may help improve thyroid function and reduce thyroid lesions in the context of Hashimoto’s disease.
Thyroid disorders may be treated using stem cell therapy
Because of their special qualities and possible therapeutic uses, MSCs may be therapeutically beneficial in the treatment of Hashimoto’s disease. MSCs are readily extracted from a variety of tissues, including the umbilical cord, adipose tissue, and bone marrow. They are also more immune system friendly due to their reduced expression of MHC antigens. Additionally, depending on the homing niche, MSCs can exhibit pro- or anti-inflammatory actions when targeting damaged organs or tissues.
MSCs’ Potential as a Treatment for Hashimoto’s Thyroiditis
The symptoms of Hashimoto’s thyroiditis, an autoimmune thyroid disease (AITD), include parenchymal atrophy, fibrotic alterations, and lymph cell infiltration. According to studies, MSCs made from human foetal umbilical cord tissue can reduce thyroid lesions and lymphoid infiltration, which can be therapeutically advantageous in rat models of Hashimoto’s illness. The alteration of Th17/Treg cell balance is the main mechanism behind this impact.
MSCs in Gene Therapy for Autoimmune Thyroiditis
MSCs have also been used to treat autoimmune thyroiditis in conjunction with gene therapy. Human adipose tissue-derived MSCs (hATMSC) and gene-transduced hATMSC both restore the Th1/Th2 balance and reduce the synthesis of proinflammatory cytokines. These results imply that MSCs’ immunomodulatory qualities and capacity to lessen inflammation and thyroid lesions may make them an important part of the treatment of Hashimoto’s illness.