UC-MSCs for Diabetic Wound Healing Stem Cell Therapy Thailand
The incidence of metabolic disorders is increasing, and among them, diabetes mellitus is the most deleterious. The most severe and common complication of diabetes is the development of chronic, non-healing ulcers. These Wound can lead to life-threatening infections and necessitate amputations. Each failed treatment further diminishes the patient’s quality of life. To break this cycle, more effective treatments are needed. A significant number of scientists are actively focusing on regenerative medicine and, more specifically, on umbilical cord-derived mesenchymal stem cells (UC-MSCs). Their focus is on targeting and healing tissues that become chronically inflamed and are insufficiently perfused in Diabetic patients. Consequently, clinics in Thailand now offer Diabetic Wound Healing Stem Cell Therapy to patients with diabetes who struggle to heal due to the aforementioned cellular alterations.
1.Causes of Diabetic Wound and life Impaction
One of the variables Diabetic ulcers is that people with diabetes have impaired natural healing processes. In normal physiology, wound healing occurs in 4 phases that is hemostasis, inflammation, proliferation and remodeling ones. Diabetic patients undergo prolonged phases of wound healing due to their hyperglycemic state that causes increased production of Reactive Oxygen Species (ROS), and Advanced Glycation End-products (AGEs). The inflammatory phase of a wound is prolonged due to a number of biochemical reactions and inflammatory processes, specifically produced by inflammatory cytokines (PICs) that drive the production of TNF-α and IL-1β. The uncontrolled inflammation results in a wound that fails to progress to a proliferation phase. In diabetes, there is also a lack of angiogenesis, which is the supply of critical nutrients and oxygen to the wound and surrounding area, and essential for the healing process. Due to these factors, the affected tissue suffers from necrosis (ischemia) and also provides a suitable environment for the proliferation of antibiotic-resistant bacteria.
- Traditional therapeutic modalities of Diabetic Wound
The Standard of Care (SOC) is the basis for most Diabetic Wound Healing strategies. The SOC focuses on precise tissue debridement to remove necrotic tissue, offloading the wound to reduce pressure, and the use of dressings that keep the wound in a moist state to optimize healing. While these techniques are focused on preserving less damaged tissue and promoting a clean wound bed, they fail to consider the importance of the absent cellular components. Thus, the presence of proteins in the wound bed, which are short-lived, is a critical limiting factor to the success of newer dressings and topical growth factors. Many patients participate in traditional therapeutic modalities for long period of time, frequently for many months or in some cases, many years. Unfortunately, the ulcer does not completely heal. There are some limits. These limits present themselves when the practice of conventional medicine is applied to the surface of the wound, treating the wound symptoms, while ignoring the root causes of the dysfunctional and unhealthy cellular environment.
3.The advantages of UC-MSCs
The advantage of UC-MSCs is attributed to its origin. UC-MSCs have the ability to proliferate and modulate the immune system more effectively than other stem cells. In case of chronic ulcers, those cells serve as a biological reservoir of some paracrine factors. In the case of an ulcer, these cells release paracrine factors such as Transforming Growth Factor-β and Vascular Endothelial Growth Factor. It is believed that those factors will have an impact through one or both of the following ways. They help the body to reduce the inflammatory response by switching macrophages from a pro-inflammatory M1 phenotype to a pro-healing M2 phenotype. They also promote angiogenesis by increasing the blood flow to previously ischemic tissues. The objective of using such cells in Diabetic Wound Healing Stem Cell Therapy in Thailand is to restore the wound microenvironment and to stimulate fibroblasts to migrate, synthesize, and organize the fibrous collagen matrix, which is the primary structural element that supports the tissue.
4.The Emerging in the forefront of regenerative medicine in Thailand
Thailand has constructed sophisticated laboratories and set processes to ensure the safety, effectiveness, and quality of cellular therapies. With extensive and complicated biology treatment systems, Thailand has been able to design a full functioning ecosystem to encourage and facilitate the development of new clinical methodologies and treatments for diabetes and its ensuing complications. With the diabetes and its complications clinics, Thailand has integrated the regenerative personalized medicine and the diabetes and its complications clinics. Stem Cell Therapy to treat Diabetic wound employing highly sophisticated technology and therapeutic approach is unique to Thailand. The ability to treat non-healing ulcers using this technique demonstrates Thailand’s cellular technology and clinical expertise.
Regenerative therapy is set to replace palliative wound care in the treatment of diabetes. This means we can go beyond having to provide Diabetic wound with only topical solutions and address more complex aspects of the healing. More than just biological surface changes. UC-MSCs can eliminate several of the barriers to healing that are present. This is particularly important in the case of Diabetic wound as they are more often resistant to healing. The ideal outcome from a medical point of view is to avoid a partial amputation which is due to the loss of blood circulation and as a result poor wound healing prolongs the life of the patient. Thailand’s progress in Stem Cell Therapy for wound care is likely to change the current practices of regenerative medicine to improve the application of Stem Cell Therapy for patients with Diabetic foot wound in a situation where lower limb amputation is required to relieve the patient and thus restore their social dignity.